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Epileptic discharges are typically focal but may become widespread and are frequently associated with seizures (27)

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TH regulation is a particularly intricate example of feedback control: dopamine (the first catecholamine product) binds the Fe²⁺ center in the TH active site, and this binding stabilizes an interaction between the N-terminal regulatory domain α-helix (containing Ser40) and the catalytic domain, physically occluding the substrate binding site and preventing both L-DOPA synthesis and dopamine egress